CompuGene Seminar Series – Upcoming Talks
All guests are very welcome!
November 8, 2017 – B2|03 – 109 (4 p.m.)
Dr. Rodrigo Lesdema Amaro
Imperial College London, UK
„Multilevel strain engineering in Yarrowia lipolytica for the production of fuels and chemicals”
o Synthetic Biology: The group is interested in using and developing new synthetic biology tools that allow us to precisely manipulate microbial cells in a reliable, predictable and standardized way. In particular, we are interested in those cutting edge techniques that permit a fine tuning of metabolic pathways.
o Metabolic Engineering: The manipulation and optimization of microbial metabolic pathways are the keys for biotechnology and a bio-based economy. The research group is highly interested in hacking metabolism using synthetic biology tools to create new properties and enhanced behaviors in microbial cells. The engineering strategies are not only designed to produce new high-value products or higher amount of pre-existing products but also to facilitate the downstream and upstream parts of the bioprocesses.
o Microbial biotechnology and Microbial communities: Microorganisms are important for both industrial bioprocesses and biomedicine (i.e. gut or skin microbiota). The lab is interesting in a wide array of organisms, from yeast (S. cerevisiea and Y. lipolytica), fungus (A. gossypii) and bacteria (E.coli and Acetobacter) to complex microbial consortia (human and industrial microbiota).
o Applications in Industrial biotechnology and biomedicine: As a summary the lab is interested in applying the engineered microorganisms using synthetic biology to the production of 1) high-value chemicals and fuels (biodiesel, lipid-derived compounds, food additives, etc) 2) biomaterials for biomedicine and environmental applications (bacterial cellulose) and 3) understanding microbiome and dysbiosis leading to diseases (skin microbiome, wound healing).
November 8, 2017 – B2|03 – 109 (5 p.m.)
Dr. Geoff Baldwin
Imperial College London, UK
“An integrated workflow for synthetic biology: from parts to systems and the evolution of new function”.
Research work in the Baldwin lab focuses on the development of synthetic biology approaches to facilitate the engineering of new biological systems for real-world applications. To this end we have developed foundational tools, like our BASIC DNA assembly method, that transform our ability to rapidly prototype new biological designs. We are also developing enhanced methods for accurate metrology to better understand and model the relationship between input design and phenotypic response. These fundamental developments are being applied across a broad range of projects that address gene circuit design; RNA feedback control; in vivo directed evolution for the generation of new protein specificity and functionality; engineering protein nanocages as vectors for targeted drug delivery.”
December 6, 2017 – B2|03 – 109 (5 p.m.)
PD Dr. phil. Joachim Boldt,
Institut für Ethik und Geschichte der Medizin,