Seminar Series

CompuGene Seminar Series – Upcoming Talks

All guests are very welcome!


March 7, 2018 – Bio Campus (4 p.m.)

Prof. Eckhard Boles (Frankfurt),

Boles Group (Frankfurt)

The classical human interest into yeasts, lower unicellular eukaryotes, stems from their well-known role in the preparation of wine, beer, and bread. In the last decades attention has focused on some additional functions for yeasts as well as scientific model organisms but also in their use for industrial or medical purposes. Today, yeasts cells are not only indispensable for fundamental research but belong to the most important organisms in industrial biotechnology. The Boles group is using yeasts to study general metabolic and regulatory processes, and is developing technologies to improve the applications of yeasts in biotechnology.

Projects include:

Butanol and aromatic compounds

  • Short-chain fatty acids, higher alcohols and polyketides
  • C5-Technology: Fermentation of pentose sugars with recombinant yeasts
  • Sugar uptake and human glucose transporters
  • Synthetic organelles and compartmentalization

Prof. Uwe Bornscheuer (Greifswald),

Bornscheuer Group (Greifswald)

Overview of research activities:

Access to biocatalysts

  • Identification of new biocatalysts by screening, e.g. from strain collections
  • In silico discovery of novel enzymes
  • Cloning and functional expression in suitable microbial hosts
  • Creation of tailor-made enzymes using directed (molecular) evolution and rational protein design
  • Commercial enzymes


  • Development of High-Throughput-Systems for directed evolution
  • Development & application of bioinformatic tools
  • Cloning, expression, purification, characterization of enzymes
  • Chemical syntheses
  • Chiral analysis (e.g. via gas chromatography or HPLC)
  • Process development (e.g. continuous enzymatic synthesis)

Enzymes studied

  • Transaminases
  • Baeyer-Villiger Monooxygenases
  • Esterases/Lipases
  • Oxidases
  • Others


  • Synthesis of optically pure compounds, e.g. for pharmaceutical applications
  • Modification of fats and oils, e.g. structured triglycerides
  • Synthesis of detergents, e.g. sugar esters